Liposomal Curcumin for Non-alcoholic Fatty Liver Disease (NAFLD)


In a randomized placebo control study of 52 subjects with Non-alcoholic Fatty Liver Disease (NAFLD) those who took 500 mg twice daily of liposomal curcumin (an extract from Turmeric) had obvious improvement in liver enzymes and ultrasonic imaging. Levels of liver enzyme decreased and levels of liver fat decreased after an 8 week treatment compared to the control group. Ultra-sonographic findings were improved in 75.0% of subjects in the curcumin group, while the rate of improvement in the placebo group was 4.7% (Panahi et al., 2017)

NAFLD is common problem in adults and is considered the hepatic (liver) manifestation of metabolic syndrome. But it is also a concerning problem in children. In obese children from industrialized countries, NAFLD prevalence is up to 80%, with a male-to-female ratio of 2: 1. It’s thought to be primarily caused by insulin resistance but other known causes are discussed such as Small Intestinal Bacterial Overgrowth (Shanab et al., 2011) and Toxin Associated Steatohepatitis (TASH) (Patrick, 2015

In NAFLD the liver cells called hepatocytes get infiltrated with fat (steatohepatitis) and the liver architecture begins to change. There is inflammation leading to steatohepatitis and inflammation because of steatohepatitis. It has the potential to progress to non-alcoholic steatotic hepatitis (NASH). Once the liver progresses to NASH there is greater potential develop fibrosis and cirrhosis leading to portal hypertension, liver decompensation, and hepatocellular carcinoma. Liver failure is a serious problem and leads to a high risk of mortality.


Nash Progression (www.atlasofscience.org)

As mentioned, another subset of steatohepatitis is called Toxin Associated Hepatitis (TASH). The t